furegrelate是一种高度选择性的血栓素合成酶抑制剂,它具有水溶性和化学稳定性好的优点,作者研究了本品对人体血栓素合成酶活性和血小板功能的影响。试验采取单盲法,将20名18～50岁的健康男性志愿受试者随机分为5组,在禁食过夜后分别给予单剂furegrelate 200,400,800,1600 mg 或安慰剂口服,定期抽取受试者服药前、后的静脉血样,并收集尿液,用HPLC法测定本品浓度,并用Peyton 凝聚计测定血 Furegrelate is a highly selective thromboxane synthase inhibitor with water-solubility and good chemical stability. The authors studied the effects of this product on thromboxane synthetase activity and platelet function in humans. In the test, 20 healthy male volunteers aged 18 to 50 years were randomly divided into five groups and were given a single dose of furegrelate 200, 400, 800, 1600 mg or placebo orally after a fasting overnight. The subjects were regularly taken Before taking medicine, after the venous blood samples, and urine collected by HPLC determination of the concentration of this product, and measured with Peyton condensate blood