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目的 探讨老年人医院内感染与自然杀伤细胞活性及血清免疫球蛋白关系的前瞻性研究。方法１９９３～１９９５年随机为门诊对象检测自然杀伤细胞活性及免疫球蛋白，然后前瞻性跟踪调查１９９６年１月至１９９７年１２月老年病房收治的６０岁以上患者，观察老年人医院内感染与自然杀伤细胞活性及免疫球蛋白的关系。结果 共１６９例事先检测自然杀伤细胞活性者住院，内１１３例发生医院内感染。在ＮＫ细胞活性＜２０％组中，发生医院内感染者７７例，高达７６．２４％，未发生医院内感染者２４例，仅占２３．７６％，而ＮＫ细胞活性≥２０％者则分别为５２．９４％及４７．０６％，有显著差异（ｘ～２＝９．９５，Ｐ＜０．０１），血清免疫球蛋白水平与有医院内感染及无医院内感染之相对百分率无明显相关。结论 老年人自然杀伤细胞活性偏低者易并发医院内感染。
Objective To explore a prospective study on the relationship between nosocomial infection and natural killer cell activity and serum immunoglobulin in the elderly. Methods From 1993 to 1995, natural killer cell activity and immunoglobulin were randomly detected in outpatients, and then prospectively follow-up investigation of patients older than 60 years old admitted to the ward of elderly ward from January 1996 to December 1997 to observe the relationship between nosocomial infection and nature Killer cell activity and immunoglobulin. Results A total of 169 patients were tested for natural killer cell activity before hospitalization and 113 patients developed nosocomial infection. In NK cell activity <20% group, 77 cases occurred in hospital, up to 76.24%, 24 cases did not occur in hospital, accounting for only 23.76%, while those with NK cell activity≥20% (52.94%) and 47.06% (x ~ 2 = 9.95, P <0.01). The relative percentage of serum immunoglobulin levels in patients with nosocomial infection and nosocomial infection was insignificant Related. Conclusion The elderly with low activity of natural killer cells easily complicated by nosocomial infections.