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所谓药物中毒是指由于药物的正常药理作用过度所产生的不利的药物作用。这一定义提示,药物中毒是一种与剂量相关的现象,其发生取决于以下三种机制:(1)药理学机制:由于药物总量的增加所致。(2)药代动力学机制:药物剂量不变,而药物作用部位的浓度升高。(3)药效学机制:药物在作用部位的浓度不变,而一定浓度的药物其药理作用增强(即组织对药物作用的反应性增高)。按这些机制可将洋地黄中毒的发生因素分为以下几点。药理学机制
The so-called drug poisoning is due to the adverse effects of the drug’s normal pharmacological effects produced by the adverse drugs. This definition suggests that drug poisoning is a dose-related phenomenon that occurs depending on the following three mechanisms: (1) Pharmacological mechanisms: due to an increase in the total amount of the drug. (2) Pharmacokinetic mechanism: the drug dose unchanged, and the concentration of the drug action site increased. (3) Pharmacodynamic mechanism: the concentration of the drug at the site of action is unchanged, and the pharmacological effect of the drug at a certain concentration is enhanced (that is, the reactivity of the tissue to the drug is increased). According to these mechanisms digitalis poisoning can be divided into the following factors. Pharmacological mechanisms