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自的探讨NIDDM患者自主神经病变（AN）与糖尿病肾病（DN）的关系。方法测定了68例NIDDM患者的HbAlc、血脂、24小时动态血压（AMBP）、尿白蛋白排泄率（UAER）及自主神经功能（ANF）。以健康对照心率功率谱变量95％可信区间作为ANF正常参考值，将NIDDM，患者分成伴AN和无AN组。结果伴AN患者血压、心率、UAER24，小时均值显著高于无AN组，其昼夜变异率[△0（d—n）％]显著低于无AN组，且伴AN患者血压和相应UAER相关性更好。多元逐步回归分析表明血压、HbAlc、超低频段功率（PVV）是影响UAER的主要因素。结论AN是与DN密切相关的因素，其可能在DN发生发展过程中起重要作用。
Since the relationship between NIDDM patients with autonomic neuropathy (AN) and diabetic nephropathy (DN). Methods HbA1c, blood lipid, 24-hour ambulatory blood pressure (AMBP), urinary albumin excretion rate (UAER) and autonomic nervous function (ANF) were measured in 68 patients with NIDDM. The 95% confidence interval of power spectrum variables of healthy control heart rate was taken as the normal reference value of ANF. Patients with NIDDM were divided into AN group and no AN group. Results The blood pressure, heart rate, UAER24 and hourly mean of patients with AN were significantly higher than those without AN and the day-night mutation rate was significantly lower than that of patients without AN (AN). The blood pressure and the corresponding UAER better. Multivariate stepwise regression analysis showed that blood pressure, HbAlc, ultra-low frequency power (PVV) are the main factors affecting UAER. Conclusion AN is a closely related factor with DN, which may play an important role in the development of DN.