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目的：探讨细胞色素 P450 2E1基因多态与肝癌的关系。方法：应用 PCR RFLP方法对 84例肝癌患者和 144例健康对照的细胞色素 P450 2E1基因 Rsa I多态进行检测。结果：病例组基因型 A频率为 71.43％，等位基因 c1频率为 84.52％，对照组则分别为 55.56％和 75.35％，两组差别均有统计学意义 (P0.05)。结论：细胞色素 P450 2E1基因 Rsa I多态位点的基因型 A或等位基因 c1增加了个体患肝癌的危险性。
Objective: To investigate the relationship between polymorphism of cytochrome P450 2E1 gene and liver cancer. Methods: The polymorphism of cytochrome P450 2E1 gene Rsa I in 84 patients with liver cancer and 144 healthy controls was detected by PCR RFLP. Results: The genotype A frequency in the case group was 71.43%, the allele c1 frequency was 84.52%, and the control group was 55.56% and 75.35% respectively. There was a statistically significant difference between the two groups (P<0.05). CONCLUSIONS: Genotype A or allele c1 of the Rsa I polymorphic locus of the cytochrome P450 2E1 gene increases the risk of developing liver cancer in individuals.