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目的探讨急性心包炎患者血清肌钙蛋白I(cTnI)浓度与ST段抬高的关系。方法应用酶联免疫荧光法测定81例急性心包炎患者血清cTnI浓度,其中cTnI≥0.35μg/L为阳性,心肌梗死的诊断阈值为1.5μg/L。结果cTnI阳性41例,其中ST段抬高29例(71%);cTnI阴性40例,其中ST段抬高25例(62.5%),二者比较有显著性差异(P<0.05)。cTnI≥1.5μg/L 21例,其中ST段抬高20例(95%);cTnI<1.5μg/L 60例,其中ST段抬高31例(52%),二者比较有显著性差异(P<0.001)。结论急性心包炎患者可根据cTnI浓度判断心肌损伤程度,虽然单有ST段抬高不一定有心肌损害,但ST段抬高患者中cTnI浓度明显升高者提示有心肌损伤。
Objective To investigate the relationship between serum cTnI concentration and ST segment elevation in patients with acute pericarditis. Methods Serum cTnI levels in 81 patients with acute pericarditis were determined by enzyme-linked immunosorbent assay. The cTnI≥0.35μg / L was positive, and the diagnostic threshold of myocardial infarction was 1.5μg / L. Results There were 41 cases of cTnI positive, of which 29 cases (71%) had ST elevation and 40 cases had negative cTnI. Among them, 25 cases (62.5%) had ST elevation. There was significant difference between the two groups (P <0.05). There were 21 cases of cTnI≥1.5μg / L, of which 20 cases were ST segment elevation (95%), 60 cases were cTnI <1.5μg / L, of which 31 cases were ST elevation (52%) P <0.001). Conclusions Patients with acute pericarditis can determine the extent of myocardial injury according to the concentration of cTnI. Although ST-segment elevation alone may not have myocardial damage, myocardial infarction may be induced by elevated cTnI levels in patients with ST elevation.