[目的]检测氯化苦经消化道、皮肤和呼吸道3种暴露途径引起动物的中毒症状、死亡率及半数致死剂量,为急性毒性分级和生产使用防护提供科学的资料。[方法]GB 15670—1995《农药登记毒理学试验方法》中急性经口、经皮、吸入染毒方法。[结果]氯化苦急性经口LD50:雌性为369(271~501)mg/kg,雄性为316 mg/kg,经皮LD50雌雄大鼠均为926(636~1 350)mg/kg,吸入LC50(2 h)雌雄大鼠均为316 mg/m3。[结论]该实验室条件下,氯化苦对大鼠急性经口、经皮、吸入毒性均属于中等毒。 [Objective] To detect poisoning symptoms, mortality and median lethal dose caused by three exposure routes of chloropicrin via the digestive tract, skin and respiratory tract, and provide scientific information for the classification of acute toxicity and protection of production and use. [Method] Acute oral, percutaneous, inhalation and exposure methods to GB 15670-1995 “Toxicological test method for registration of pesticides”. [Results] The acute oral LD50 of chloropicrin was 369 (271 ~ 501) mg / kg for females, 316 mg / kg for males and 926 (636 ~ 1 350) mg / kg for LD50 rats. LC50 (2 h) male and female rats were 316 mg / m3. [Conclusion] Under the laboratory conditions, chloropicrin on rats acute oral, dermal, inhalation toxicity belong to moderate toxicity.