百草枯属于剧毒类除草剂,中毒后主要导致肺、肝、肾等重要脏器损害,其中以肺组织损伤为主。目前尚无特效解毒剂,治疗困难,病死率高,早期中毒患者多死于多脏器损害,后期多死于肺纤维化。目前在临床上主要给予早期清除毒物、血液灌流、血液透析和保护重要脏器等治疗。由于百草枯中毒的发病机制尚不明确,因此寻求其发病机制和有效的药物治疗已成为研究热点。 Paraquat belongs to the highly toxic herbicide. After being poisoned, the paraquat mainly causes damage to important organs such as the lung, liver and kidney, and the lung tissue is the main one. Currently there is no effective antidote, treatment difficulties, high mortality, early poisoning patients died of multiple organ damage, more died later in the lung fibrosis. At present, the main clinical early give clear poison, hemoperfusion, hemodialysis and protection of vital organs and other treatment. As the pathogenesis of paraquat poisoning is not clear, seeking its pathogenesis and effective drug treatment has become a research hotspot.