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目的研究上皮性钙黏附蛋白(E-cad)和α-连接蛋白(α-Cat)的表达与大肠癌生物学行为的关系。方法应用免疫组织化学SP法分别检测62例大肠癌及15例正常大肠黏膜组织中E-cad和α-Cat的表达。结果大肠癌组织中E-cad和α-Cat阳性表达率分别为54.8%和50.0%,均明显低于正常大肠黏膜组织,差异有高度统计学意义(P<0.01)。E-cad和α-Cat表达与大肠癌的分化程度和淋巴结转移密切相关(P<0.05),且两者表达成明显正相关(P<0.05)。结论E-cad和α-Cat的检测可以作为临床判断大肠癌的恶性程度和转移的重要参考指标。
Objective To study the relationship between the expression of epithelial cadherin (E-cad) and α-catenin (α-Cat) and the biological behavior of colorectal cancer. Methods Immunohistochemical SP method was used to detect the expression of E-cad and α-Cat in 62 cases of colorectal carcinoma and 15 cases of normal colorectal mucosa. Results The positive rates of E-cad and α-Cat in colorectal carcinoma were 54.8% and 50.0%, respectively, which were significantly lower than those in normal colorectal mucosa (P <0.01). The expression of E-cad and α-Cat was closely related to the differentiation and lymph node metastasis of colorectal carcinoma (P <0.05), and the expressions of E-cad and α-Cat were positively correlated with each other (P <0.05). Conclusion The detection of E-cad and α-Cat can be used as an important reference for judging the malignant degree and metastasis of colorectal cancer clinically.