论文部分内容阅读
目的通过抗幽门螺杆菌(HP)治疗探讨HP与复发性口腔溃疡(ROU)的相关性分析。方法应用二氧化硅微粒法提取DNA,并进行PCR检测HP法检测所有ROU患者口腔中的标本,选取HP阳性的ROU患者40例,随机分为治疗组与对照组,对照组患者给予RAU常规治疗2周,甲硝唑0.4g/次,每日3次,局部用口腔溃疡散涂布,治疗组用三联疗法治疗:丽珠得乐饭前半小时110mg/次,每日4次;阿莫西林胶囊1.0g/次,每天3次;甲硝唑0.4/次,每日3次。连续两周,局部给以溃疡散涂布。于治疗结束后检测患者口腔中HP。治疗后半年统计两组患者的复发率。结果治疗结束后,治疗组中有4例出现HP阳性,阳性率为20%,对照组有7例出现HP阳性,阳性率35%,二者差异有统计学意义,P<0.05;治疗后半年复查,所有患者均到访,治疗组患者中有9例复发,复发率45%,对照组患者中有13例复发,复发率65%,二者差异有统计学意义,P<0.05。结论通过三联治疗HP降低了ROU患者的复发率,说明HP与ROU具有一定的相关性。
Objective To investigate the correlation between HP and recurrent oral ulcer (ROU) by anti-Helicobacter pylori (HP) treatment. Methods DNA was extracted by silica particle method and detected by PCR. All samples were collected from the mouth of all ROU patients. 40 patients with HP positive ROU were randomly divided into treatment group and control group, while patients in control group were given RAU routine treatment 2 weeks, metronidazole 0.4g / time, 3 times a day, topical oral ulcers scattered coating, the treatment group with triple therapy: Lizhu was half an hour before lunch 110mg / times, 4 times a day; amoxicillin Capsule 1.0g / time, 3 times a day; metronidazole 0.4 / times, 3 times a day. For two consecutive weeks, the local to the ulcer scattered coating. The patient’s mouth was examined for HP after treatment. Six months after treatment, the recurrence rates of two groups were calculated. Results After the treatment, 4 cases in the treatment group appeared positive for HP, the positive rate was 20%. In the control group, 7 cases showed HP positive, the positive rate was 35%, the difference was statistically significant, P <0.05; Review, all patients were visited, the treatment group, 9 patients relapsed, the recurrence rate was 45%, 13 patients in the control group of recurrence, the recurrence rate was 65%, the difference was statistically significant, P <0.05. Conclusions Triple therapy of HP reduces the recurrence rate of patients with ROU, indicating that HP and ROU have a certain correlation.