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目的研究讨论激素治疗丙种球蛋白治疗无效型川崎病的效果。方法选取我科2011年1月~2015年3月收治疗诊断为川崎病的婴幼儿，经正规丙种球蛋白和阿司匹林治疗疗效不佳病人39例,随机分为治疗组给予小剂量甲强龙治疗，对照组给予再次丙种球蛋白治疗，两组均辅以物理退热、阿司匹林口服等对症支持治疗。观察两组患儿在治疗后发热、血沉、CRP降至正常和住院天数上的对比情况；2年随访冠状动脉病变发生率和预后差异情况。结果两组患儿治疗后发热、血沉、CRP指标均明显缓解；且治疗组同期指标及住院天数均优于对照组(均<0.05)；两组治愈出院后2年随访冠状动脉病变发生率和预后无明显差异。结论激素治疗丙种球蛋白治疗无效型川崎病疗效肯定，患儿症状缓解和住院时间优于对照组，2年随访冠状动脉病变发生率和预后无明显差异。“,”Objective To investigate the hormone treatment of gamma globulin therapy type Kawasaki disease effect.Methods In our department from January 2011 to March 2015 received the diagnosis and treatment of Kawasaki disease in infants and young children, the poor efficacy of normal gamma globulin protein and aspirin in the treatment of patients in 39 cases randomly divided into treatment group given small dose methylprednisolone treatment, control group was given again gamma globulin in the treatment, two groups were supplemented by physical fever, oral aspirin symptomatic support treatment. Observe all patients of the two groups after treatment of fever、ESR、CRP fell to normal and hospitalization days compared;2 year follow up of coronary artery lesions occur rate and prognosis of difference. Results The two groups after treatment in children with fever、ESR and CRP were significantly alleviated; and the treatment group at the same time index and length of hospital stay were better than control group ( < 0.05); group 2 cured and discharged after 2 years follow-up of coronary artery lesions occur rate and prognosis had no significant difference. Conclusion Glucocorticoid treatment for gamma globulin treatment Kawasaki disease curative effect affirmation is invalid, children with symptoms remission and hospitalization time was superior to the control group, 2 year follow up of coronary artery lesions occur rate and prognosis had no significant difference.