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目的用蒿甲醚与吡喹酮联合治疗急性日本血吸虫病,评估联合用药的临床疗效和安全性。方法96例急性日本血吸虫病人完全随机分为2组,治疗组45例口服蒿甲醚6mg/kg加吡喹酮120mg/kg联合治疗,对照组51例口服安慰剂加吡喹酮120mg/kg。比较两组治愈率、治后21、45天粪便虫卵阴转率及减卵率、用药后不良反应发生率。试验采用双盲法。结果治疗组与对照组治愈率分别为97.7%和95.7%,治后45天粪便减卵率分别为99.1%和97.7%,治疗后平均发热天数分别为5.1d和4.5d,平均住院天数分别为9.4d和8.9d,差异均无显著性(P均>0.05)。治疗组2例病人口服蒿甲醚后腹部和背部出现荨麻疹,对症处理后症状消失;1例出现呕吐。结论蒿甲醚与吡喹酮联合治疗急性血吸虫病安全,无明显不良反应,治疗效果与单用吡喹酮无明显差异。
Objective To evaluate the clinical efficacy and safety of combination therapy with artemether and praziquantel in the treatment of acute schistosomiasis japonica. Methods A total of 96 patients with acute schistosomiasis japonicum were randomly divided into two groups. The treatment group received oral administration of artemether 6 mg / kg plus praziquantel 120 mg / kg. The control group received oral administration of praziquantel 120 mg / kg. The cure rates of the two groups were compared. The negative conversion rates and the egg reduction rates of the fecal eggs were 21 and 45 days after the treatment, and the incidence of adverse reactions after the treatment. Test using double-blind method. Results The cure rates of the treatment group and the control group were 97.7% and 95.7%, respectively, and the rates of feces reduction were 99.1% and 97.7% respectively after 45 days of treatment. The mean days of fever after treatment were 5.1 days and 4.5 days respectively, and the average hospitalization days were 9.4d and 8.9d, no significant difference (P> 0.05). Two patients in the treatment group showed urticaria on the abdomen and back after oral administration of artemether, symptoms disappeared after symptomatic treatment, and vomiting occurred in one patient. Conclusions The combination of artemether and praziquantel in the treatment of acute schistosomiasis is safe and has no obvious adverse reactions. The treatment effect is no significant difference with praziquantel alone.