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对36例健康志愿者及31例有高血压、高脂血症患者的全血比粘度、血浆比粘度、红细胞压积、血浆纤维蛋白原含量及红细胞变形性等血液流变学指标进行了昼夜24小时的动态监测,取血时点分别为6:00、12:00、18:00、24:00,各指标测定分别采用毛细管粘度计法,微管离心沉淀法,双缩脲法及激光衍射法。结果表明除红细胞变形指数外,余各指标均存在一昼夜24小时的波动性变化,其中全血比粘度、血浆比粘度以及血浆纤维蛋白原含量,在早6:00时的数值显著高于24:00时的数值,这为脑血管病的防治提供了新的线索。
The indexes of hemorheology, such as whole blood viscosity, plasma specific viscosity, hematocrit, plasma fibrinogen content and erythrocyte deformability in 36 healthy volunteers and 31 patients with hypertension and hyperlipidemia, were observed day and night 24 hours of dynamic monitoring, blood collection points were 6:00, 12:00, 18:00, 24:00, respectively, the determination of the indicators were used capillary viscometer, microtubule centrifugation, biuret method and the laser Diffraction method. The results showed that in addition to the index of erythrocyte deformation, the remaining indicators of the 24-hour fluctuations in the presence of a day and night, of which the whole blood viscosity, plasma viscosity and plasma fibrinogen content as early as 6:00 when the value was significantly higher than 24: 00 when the value, which provides a new clue for the prevention and treatment of cerebrovascular disease.