核因子-KappaB(NF-κB)是细胞中一个重要的核转录因子,NF-κB是1986年从B细胞核抽提物中找到的转录因子,能与免疫球蛋白κ轻链基因增强子B序列GGGACTTTCC特异性结合,并能促进κ轻链基因表达[1]。现已证明NF-KB是一种具有转录激活功能的蛋白质,它能与多种基因启动子或增强子部位 Nuclear factor-kappaB (NF-κB) is an important nuclear transcription factor in cells. NF-κB is a transcription factor found in B cell nuclear extracts in 1986 and binds to immunoglobulin κ light chain enhancer B sequence GGGACTTTCC specific binding, and can promote kappa light chain gene expression [1]. It has been demonstrated that NF-KB is a transcription-activating protein that interacts with multiple gene promoters or enhancer sites