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研究观察年龄对潘库溴铵药代动力学的影响。选择２４例施择期整形外科手术的患者，根据年龄分成三组：１组为５例婴幼儿，年龄０．７５～２．９５岁；２组为１３例儿童，年龄４～１４岁；３组为６例成人，年龄１６～２７岁。静注潘库溴铵１００μｇ／ｋｇ后用改良荧光法测定其血浓度。潘库溴铵的体内过程能用二室开放模型完整描述，年龄愈小，分布容积愈大，血浆清除率愈高，潘库溴铵的血药浓度愈低。Ｖ１（中央室分布容积）、Ｖ２（周边室分布容积）、Ｖｄｓｓ（稳态分布容积）、Ｃｌ（血浆清除率）和ＡＵＣ（曲线下面积）在三组间有明显差别。１组的Ｔ１／２β和ＭＲＴ明显比２、３组长，但Ｔ１／２α和Ｋ２１在三组间无明显差别。
The effect of observed age on the pharmacokinetics of pancuronium was investigated. Twenty-four patients undergoing orthopedic surgery were divided into three groups according to age: group 1 was 5 infants and children aged 0.75-2.95 years; group 2 was 13 children aged 4-14 years; group 3 6 adults, aged 16 to 27 years old. After intravenous injection of pancuronium 100μg / kg, the blood concentration was measured by modified fluorescence method. The in vivo process of pancuronium can be completely described by a two-compartment open model. The smaller the age, the larger the volume of distribution and the higher the plasma clearance rate, the lower the plasma concentration of pancuronium. V1 (central compartment volume), V2 (peripheral compartment volume), Vdss (steady state volume of distribution), Cl (plasma clearance), and AUC (area under the curve) were significantly different among the three groups. T1 / 2β and MRT in group 1 were significantly longer than those in group 2 and 3, but T1 / 2α and K21 had no significant difference among the three groups.