论文部分内容阅读
近年来,对肿瘤干细胞巢的深入研究开启了肿瘤研究的“巢”时代,结直肠癌是实体肿瘤的典型代表,有较为典型的发生发展机制,是肿瘤干细胞巢研究的可靠模型.潘氏细胞是正常肠上皮的重要组成细胞,对肠干细胞具有重要的支持、保护等作用,是肠干细胞巢的关键成分之一.然而目前在结肠上皮恶性转化中,以潘氏细胞为代表的干细胞巢成分的作用如何尚有待研究,进一步研究潘氏细胞和肠干细胞的相互关系,从而推导其在结肠肿瘤不同发展阶段的可能作用,将有助于对肿瘤干细胞巢的进一步了解,同时也可为结直肠癌临床治疗提供潜在的新靶点.“,”In recent years,accumulating studies in cancer stem cells niche gradually opened an era of “niche time”.As one of the classical solid tumors,colorectal cancer presented a relatively clear process of cancer initiating and development,which would be an ideal model for niche research.Paneth cells,which play a key role in supporting and protecting the intestine stem cells,are important element of normal intestinal epithelium and also one of the major components of the stem cells niche.However,the potential role of these cells,take the Paneth cells for example,on the road of colorectal epithelium malignant transformation are still largely unknown.Further studies aimed to uncover the relationship of Paneth cells with the intestine stem cells and its role in different stages of colorectal tumor development could expand the knowledge of cancer stem cells niche,also,could help to find the potential new therapeutic targets for colorectal cancer treatment in future.