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目的：探讨不同程度慢性肾病患者骨密度（BMD）及骨代谢相关指标的差异及相关关系。方法选取31例慢性肾病患者，应用双能X线（DEXA）骨密度仪测定L1～4腰椎BMD，并测定血肌酐（Scr）及骨代谢相关指标。结果Scr升高组骨代谢水平高于Scr正常组，Scr水平与降钙素（CT）、骨钙素（BGP）、甲状旁腺素（PTH）、碱性磷酸酶（ALP）呈正相关（r=0.67、0.81、0.85、0.45，P＜0.05），与BMD T值呈负相关（r=-0.60，P＜0.01）；BMD T值与PTH及BGP呈负相关（r=-0.55、-0.65，P＜0.05）。结论随着慢性肾病的病情加重，肾性骨病呈现进展，BMD及骨代谢指标动态监测在肾性骨病的诊断及病情评估中有重要价值。“,”Objective To explore the differences and relationships between bone mineral density (BMD) and bone metabolic markers in patients with chronic renal disease of different stages. Methods BMDs of the lumbar spines were measured using dual energy X-ray absorptiometry in 31 patients with chronic renal disease. Serum creatinine (Scr)and bone metabolic were examined. Results Bone metabolic markers of group with elevated Scr were significantly higher than those of group with normal Scr. The level of Scr was positively correlated with CT, BGP, PTH, and ALP (r=0.67, 0.81, 0.85, and 0.45, P<0.05), and it was negatively correlated with the level of BMD (r=-0.60, P<0.01). The value of BMD was positively correlated with PTH and BGP (r=-0.55 and-0.65, P<0.05). Conclusion Incidence rates of renal osteopathy were closely related to the severity of chronic renal disease. Dynamic monitoring information of BMD and bone metabolic markers is important to the diagnosis and severity evaluation of renal osteopathy.