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目的观察通阳活血方对慢性充血性心力衰竭(心衰)患者心功能的影响。方法将60例符合入选标准的慢性心衰患者随机分为治疗组和对照组,各30例。对照组根据病情给予西医基础治疗(强心剂、利尿剂、血管紧张素转化酶抑制剂或血管紧张素受体拮抗剂、β受体阻滞剂及硝酸酯类药物),治疗组在对照组治疗基础上加服通阳活血方,疗程3周,分别于治疗前后检测患者血浆脑钠肽(BNP)水平并对患者进行6分钟步行试验(6MWT)。结果两组患者治疗后血浆BNP水平均较治疗前明显降低(P<0.01),且治疗组降低更显著(P<0.05);两组患者治疗后6MWT步行距离均较治疗前增加(P<0.01),且治疗组优于对照组(P<0.05)。结论通阳活血方能明显降低心衰患者血浆BNP水平,改善患者心功能,中西医结合治疗慢性心衰较单纯西医治疗效果更佳。
Objective To observe the effect of Tongyang Huoxue Recipe on cardiac function in patients with chronic congestive heart failure (HF). Methods Sixty patients with chronic heart failure who met the inclusion criteria were randomly divided into treatment group and control group, with 30 cases in each group. The control group was given western medicine based on the condition (cardiac, diuretic, angiotensin converting enzyme inhibitors or angiotensin receptor blockers, β-blockers and nitrates), the treatment group in the control group basis of treatment On the plus serving Tong Yang Huoxue side, the course of treatment for 3 weeks, respectively, before and after treatment in patients with plasma BNP levels were measured and the patient 6-minute walk test (6MWT). Results After treatment, plasma BNP levels in both groups were significantly lower than those before treatment (P <0.01), and the treatment group decreased more significantly (P <0.05). The walking distance of 6MWT after treatment in both groups was significantly higher than that before treatment (P <0.01) ), And the treatment group was better than the control group (P <0.05). Conclusion Tongyang Huoxue Decoction can significantly reduce the plasma BNP level in patients with heart failure and improve the patient’s cardiac function. The combination of TCM and Western medicine treatment of chronic heart failure is more effective than Western medicine alone.