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目的探讨血清胱抑素C(Cystatin C)在糖尿病早期诊断中的临床意义。方法 采用乳胶颗粒增强免疫比浊法(TPNIA)测定50例糖尿病患者和50例健康体检者血清胱抑素C,同时测定其血肌酐(Scr),β2-微球蛋白(β2-MG)及肌酐估算清除率,比较Cystatin C,Scr及β2-MG与Ccr估计的相关性。采用受试者工作特征曲线下面积(AUCROC)评价Cystatin C的诊断效能。结果血清Cystatin C、Scr、β2-MG与Ccr与糖尿病肾病均成显著相关,其中尤以Cysta-tin C与Ccr的相关程度最为密切。Cystatin C、Scr和β2-MG的AUCROC分别为0.984、0.922、0.947。结论 Cystatin C水平升高,能协助糖尿病肾病的早期诊断。
Objective To investigate the clinical significance of serum cystatin C in the early diagnosis of diabetes. Methods Serum levels of cystatin C in 50 patients with diabetes mellitus and 50 healthy controls were measured by latex particle-enhanced immunoassay (TPNIA). Serum creatinine (Scr), β2-microglobulin (β2-MG) and creatinine Clearance rates were estimated and the correlation between Cystatin C, Scr, and β2-MG and Ccr estimates was compared. The diagnostic efficacy of Cystatin C was evaluated using the area under the receiver operating characteristic curve (AUCROC). Results Serum Cystatin C, Scr, β2-MG and Ccr were significantly associated with diabetic nephropathy, especially Cysta-tin C and Ccr were the most closely related. The AUCROC of Cystatin C, Scr and β2-MG were 0.984, 0.922 and 0.947, respectively. Conclusions Cystatin C levels can help early diagnosis of diabetic nephropathy.