目的:评价不同镇痛方法在辅助生殖技术(Assisted Reproductive Technology)取卵术中及术后的镇痛效应、不良反应发生率及安全性。方法:选择2007年11月~2008年4月在该生殖医学中心实施辅助生殖技术(Assisted Reproductive Technology):体外授精-胚胎移植(IVF-ET)或单精子卵细胞浆内注射胚胎移植术(ICSI-ET),实施阴道超声引导下经阴道穿刺取卵术患者150例,全部病例双盲法随机分为治疗组、对照组各75例,对照组术前30 min给予40 mg杜冷丁,治疗组术前30 min给予杜冷丁40 mg,并且采用韩氏镇痛仪镇痛。结果:治疗组术中及术后患者镇痛效应与对照组比较有统计学差异(P<0.05),不良反应发生率治疗组与对照组相比无统计学差异(P>0.05),但治疗组不良反应发生频率较对照组低。结论:在辅助生殖技术(Assisted Reproductive Technology)行IVF-ET或ICSI-ET阴道超声引导下经引导穿刺取卵手术中联合应用杜冷丁加韩氏镇痛仪可大大增强镇痛效应,降低恶心、呕吐等不良反应的发生,安全性好,值得临床推广。 OBJECTIVE: To evaluate the analgesic effects, incidence and safety of different analgesic methods during and after ovulation induction by Assisted Reproductive Technology. Methods: From November 2007 to April 2008, Assisted Reproductive Technology (IVF-ET) or intracytoplasmic sperm injection (ICSI- ET), vaginal ultrasound-guided vaginal puncture 150 cases of patients, all cases of double-blind method were randomly divided into treatment group, the control group of 75 cases, the control group 30 minutes before surgery given 40 mg of pethidine, the treatment group Forte 40 mg was given in the first 30 min and analgesia was performed using a Han’s analgesic. Results: The analgesic effects in the treatment group were significantly different from those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the treatment group and the control group (P> 0.05) Adverse reactions occurred more frequently than the control group. CONCLUSIONS: Combined use of dolantinodan and Hansenolux analgesia in guided pricking and oophorectomy under the guidance of Assisted Reproductive Technology IVF-ET or ICSI-ET vaginal ultrasound can greatly enhance the analgesic effect and reduce nausea, Vomiting and other adverse reactions, good safety, it is worth clinical promotion.