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降脂治疗的时间与动脉粥样硬化斑块、组织胆固醇浓度的改变及对内皮功能恢复的关系知之较少。该研究评估了降脂治疗对上述参数的早期影响。将雄性新西兰兔随机分为6组,组1和组2喂正常饲料;组3和组4喂0.5％胆固醇饲料12周,此后用0.05％胆固醇饲料再喂养12周;组5和组6喂食0.5％胆固醇饲料12周,此后再喂以正常饲料12周。在其中最后的4周里,组1、3、5的饮食中加入低剂量普伐他汀2mg/d。
Lipid-lowering therapy time and atherosclerotic plaque, changes in tissue cholesterol concentration and the relationship between endothelial function recovery is less known. This study assesses the early effects of lipid-lowering therapy on these parameters. Male New Zealand white rabbits were randomly divided into 6 groups, group 1 and group 2 fed normal diet; group 3 and group 4 fed 0.5% cholesterol diet for 12 weeks, thereafter fed with 0.05% cholesterol diet for 12 weeks; group 5 and group 6 fed 0.5 % Cholesterol feed for 12 weeks, then fed with normal diet for 12 weeks. During the last 4 weeks, low-dose pravastatin 2 mg / d was added to the groups 1, 3 and 5 of the diet.