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目的:考察自制的肌注诺氟沙星注射剂在体内的动态行为,并与诺氟沙星胶囊剂进行比较。方法:用HPLC法测定这两种制剂在人体的血药浓度,并用非线性最小二乘法迭代程序进行数据处理。结果:注射剂在体内的过程可用开放型二室模型描述,其主要体内参数为:AUC=5.84h.μg.mL-1,Tmax=0.35
Objective: To investigate the dynamic behavior of homemade norfloxacin injections in vivo and to compare with norfloxacin capsules. Methods: The plasma concentrations of these two preparations in human body were determined by HPLC, and the data were processed by nonlinear least squares iterative procedure. Results: The in vivo process of the injection can be described by an open two-compartment model with the main in vivo parameters: AUC = 5.84 h.μg.mL-1, Tmax = 0.35