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本文观察了７６例大肠癌粘膜下浸润方式，表明间隙浸润型和淋巴小结浸润型者分别占４２．１％和１１．８％，血管浸润或淋巴管浸润型分别占２１．１％和２５．８％。组织病理学分析表明，大肠癌的分布部位和分化程度与粘膜下浸润类型无关，但血管或淋巴管浸润者，其癌细胞浸润深度和转移癌的发生率明显比间隙或淋巴小结浸润型为高。应用荆豆凝集素（ＵＥＡ－Ｉ）免疫组化技术可使血管内皮层着染，因而可容易辨认血管浸润的癌细胞团。对癌细胞ＵＥＡ－Ｉ和ＰＮＡ受体表达的分析表明，粘膜下各浸润型大肠癌，其凝集素受体表达阳性率及ＰＮＡ阳性细胞量和染色强度、类型，无明显差别，但ＵＥＡ－Ｉ的表达在血管或淋巴浸润型者呈减少趋势，提示用内镜活检粘膜标本综合评价肿瘤病变预估病变进展有参考意义。
This article observed 76 cases of colorectal cancer submucosal infiltration, indicating that the gap infiltrating type and lymph node infiltration type accounted for 42.1% and 11.8%, respectively, vascular infiltration or lymphatic infiltration type accounted for 21.1% and 25. 8%. Histopathological analysis showed that the location and degree of differentiation of colorectal cancer was not related to the submucosal infiltration type. However, invasive blood vessels or lymphatic vessels were significantly higher in the depth of cancer invasion and metastasis than in the interstitial or lymphoid infiltrates. . Utilizing the immunohistochemical technique of UEA-I, the vascular endothelial layer can be stained so that the infiltrating cancer cell mass can be easily identified. The analysis of the expression of cancer cell UEA-I and PNA receptors showed that there was no significant difference in the positive rate of lectin receptor expression and PNA-positive cells, and the intensity and type of staining of infiltrating colorectal cancers in submucosa, but UEA-I The expression of VEGF in the vascular or lymphatic infiltrative model showed a decreasing trend, suggesting that the use of endoscopic biopsy mucosa specimens comprehensive evaluation of tumor lesions to predict disease progression is of reference significance.