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目的观察糖皮质激素在治疗重度溃疡性结肠炎的临床疗效。方法选取2012年11月1日-2014年1月31日医院重度溃疡性结肠炎患者40例,随机分为治疗组和对照组各20例。对照组予基础治疗,口服氨基水杨酸制剂;治疗组在基础治疗的基础上加用糖皮质激素。第12周时观察2组治疗效果。结果治疗组总有效率为90.0%明显高于对照组的60.0%;治疗组临床缓解率为85.0%明显高于对照组的55.0%,差异均有统计学意义(P<0.05)。治疗组肠黏膜愈合率为65.0%明显高于对照组的45.0%,但2组比较差异无统计学意义(P>0.05)。结论糖皮质激素治疗重度溃疡性结肠炎有较好疗效,值得临床进一步研究。
Objective To observe the clinical effect of glucocorticoids in the treatment of severe ulcerative colitis. Methods Forty patients with severe ulcerative colitis in hospital from Nov. 1, 2012 to January 31, 2014 were randomly divided into treatment group (20 cases) and control group (20 cases). The control group was given basic treatment and oral aminosalicylic acid preparation. The treatment group was given glucocorticoid on the basis of basic treatment. At the 12th week, the treatment effect was observed in two groups. Results The total effective rate was 90.0% in the treatment group and 60.0% in the control group. The clinical remission rate in the treatment group was 85.0%, which was significantly higher than that in the control group (55.0%, P <0.05). The healing rate of intestinal mucosa in the treatment group was 65.0%, which was significantly higher than that in the control group (45.0%), but there was no significant difference between the two groups (P> 0.05). Conclusion Glucocorticoid has a good curative effect in the treatment of severe ulcerative colitis, which deserves clinical further study.