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目的:优选三虎痛风颗粒的提取工艺。方法:采用正交试验,考察加水量、提取次数、提取时间3个因素对提取工艺的影响,以虎杖苷、大黄素含量及浸膏得率为指标,采用RP-HPLC测定虎杖苷、大黄素含量,烘干法测定浸膏得率。结果:最佳提取工艺为药材加10倍量水加热回流提取2次,每次1 h。结论:该工艺设计合理,稳定可行,适用于工业化生产。
Objective: To optimize the extraction process of Gorgon Gout particles. Methods: The orthogonal test was used to study the effects of three factors on the extraction process, such as the amount of water added, the number of extraction and the extraction time. The contents of polydatin and emodin and the yield of extract were used as indexes. The concentrations of polydatin, Content, drying method to determine the extract yield. Results: The best extraction process for herbs and 10 times the amount of water heating reflux extraction 2 times, each 1 h. Conclusion: The process design is reasonable, stable and feasible, suitable for industrial production.