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AIM:To determine the survival of advanced pancreaticcancer patients treated with intraoperative radiotherapy(IORT) combined with external beam radiation therapy(EBRT) following internal drainage (cholecystojejunostomyor choledochojejunostomy).METHODS:Eighty-one patients with advanced pancreaticcancer who received IORT combined with EBRT followinginternal drainage (ID) between 1996 and 2001 wereretrospectively analyzed.Among the 81 patients,18underwent ID+IORT,25 ID+IORT+EBRT (meanwhile,given5-Fu 300mg/m~2 iv drip,2f/w),16 EBRT,22 had undergonesimple internal drainage.The IORT dose was 15-25Gy in asingle fraction.The usual EBRT dose was 30-40Gy with adaily fraction of 1.8-2.0 Gy.RESULTS:The complete remission rate,partial remissionrate of patients with backache and abdominal pain treatedwith ID+IORT were 55.5%,33.3% respectively.Alleviationof pain was observed 2 or 3 wk after IORT.The mediansurvival time (MST) of ID+IORT group was 10.7 too.Thepain remission rate of patients treated with ID+IORT+EBRTwas 92%,and their MST was 12.2 mo.The MET of patientstreated with EBRT and simple internal drainage was 5.1 moand 7.0 mo,respectively.The survival curve of ID+IORTgroup and ID+IORT+EBRT group was significantly betterthan that of EBRT group (P<0.05).The differencebetween the ID+IORT+EBRT group and ID group wassignificant (P<0.05).CONCLUSION:IORT combined with EBRT followinginternal drainage can alleviate pain,improve quality of lifeand prolong survival time of patients with advancedpancreatic cancer.
AIM: To determine the survival of advanced pancreaticcancer patients treated with intraoperative radiotherapy (IORT) combined with external beam radiation therapy (EBRT) following internal drainage (cholecystojejunostomyor choledochojejunostomy) .METHODS: Eighty-one patients with advanced pancreaticcancer who received IORT combined with EBRT followinginternal drainage (ID) between 1996 and 2001 wereretrospectively analyzed.Among the 81 patients, 18underwent ID + IORT, 25ID + IORT + EBRT (meanwhile, given5-Fu 300mg / m ~ 2iv drip, 2f / w) had undergonesimple internal drainage. IORT dose was 15-25 Gy in asingle fraction. The usual EBRT dose was 30-40 Gy with adaily fraction of 1.8-2.0 Gy. RESULTS: The complete remission rate, partial remission rate of patients with backache and abdominal pain treatedwith ID + IORT were 55.5%, 33.3% respectively. Alleviation of pain was observed 2 or 3 wk after IORT. The mediansurvival time (MST) of ID + IORT group was 10.7 too.The pain remission rate of patients treated with ID + IORT + EBRTwas 92%, and their MST was 12.2 mo. The MET of patient was with with EBRT and simple internal drainage was 5.1 mo and 7.0 mo, respectively. Survival curve of ID + IORTgroup and ID + IORT + EBRT group was highlybetterrthan that difference between the ID + IORT + EBRT group and ID group wassignificant (P <0.05) .CONCLUSION: IORT combined with EBRT following internal drainage can alleviate pain, improve quality of life and prolong survival time of patients with advancedpancreatic cancer.