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自从Nicholls和Fabozzi先后于1902年和1903年报告了第一例胰岛细胞瘤和胰岛细胞癌以来,各家对功能性胰岛细胞瘤及其分泌的激素,如胰岛素、胃泌素、高糖素以及肠血管活性肽等作了广泛深入的研究。本文复习了1960～1978年间经手术证实的168例胰岛细胞瘤,其中胰岛素瘤102例(占60％),胃泌素瘤30例(占18％),无功能性胰岛细胞瘤25例(占15％),其余8例分别为与分泌肠血管活性肽,促肾上腺皮质激素、降钙素、高血糖素、儿茶酚胺类及生长激素等有关的肿瘤。本文重点分析25例无功能性胰岛细胞瘤的资料。临床资料:25例中,男14例,女11例,平均年龄为56.8岁(24～79岁)。常见的临床征象有:腹痛9例,黄疸7例,腹块2例,腹水、精神失常及脂肪下痢者各1例。4例无症状。其他伴随的症状尚有体重减轻、倦怠、乏力及葡萄糖耐量轻度下降。临床症状与肿瘸的部位有关,
Since Nicholls and Fabozzi reported the first cases of islet cell tumors and islet cell carcinomas in 1902 and 1903 respectively, they have studied functional islet cell tumors and their secreted hormones such as insulin, gastrin, and high-glucagon. Intestinal vasoactive peptides have been extensively studied. This article reviews 168 islet cell tumors that were confirmed surgically from 1960 to 1978, including 102 insulinomas (60%), 30 gastrinomas (18%), and 25 nonfunctioning islet cell tumors (accounting for 15%). The remaining 8 cases were associated with the secretion of intestinal vasoactive peptides, adrenocorticotropic hormone, calcitonin, glucagon, catecholamines and growth hormone and other related tumors. This article focuses on the analysis of 25 cases of nonfunctioning islet cell tumors. Clinical data: In 25 cases, there were 14 males and 11 females with an average age of 56.8 years (24-79 years). The common clinical signs are: 9 cases of abdominal pain, 7 cases of jaundice, 2 cases of abdominal mass, 1 case of ascites, psychosis and fatty diarrhea. Four cases were asymptomatic. Other attendant symptoms include weight loss, fatigue, fatigue, and a slight decrease in glucose tolerance. The clinical symptoms are related to the site of the swollen fistula.