【摘 要】
：
Aim: To determine whether the anti-inflanunatory effect of minocycline on postis-chemic brain injury is mediated by the inhibition of 5-lipoxygenase (5-LOX) exp
【机 构】
：
Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China“,”Depart
论文部分内容阅读
Aim: To determine whether the anti-inflanunatory effect of minocycline on postis-chemic brain injury is mediated by the inhibition of 5-lipoxygenase (5-LOX) expression and enzymatic activation in rats.Methods: Focal cerebral ischemia was induced for 30 min with middle cerebral artery occlusion, followed by reperfusion. The ischemic injuries, endogenous IgG exudation, the accumulation of neutrophils and macrophage/microglia, and 5-LOX mRNA expression were determined 72 h after reperfusion. 5-LOX metabolites (leukotriene B4 and cysteinyl leukotrienes) were measured 3 h after reperfusion.Results: Minocycline (22.5 and 45 mg/kg, ip, for 3 d) attenuated ischemic injuries, IgG exudation, and the accumulation of neutrophils and macrophage/microglia 72 h after reperfusion. It also inhibited 5-LOX expression 72 h after reperfusion and the production of leukotrienes 3 h after reperfusion.Conclusion: Minocycline inhibited postis-chemic brain inflammation, which might be partly mediated by the inhibition of 5-LOX expression and enzymatic activation.
其他文献
根据花鲈(Lateolabrax maculatus)受精卵发育阶段以及外界环境的变化,分别采集受精后1d(胚胎)、3d(孵化破膜)、5d、6d、12d、13d、30d的胚胎和仔稚鱼作为实验样品,测定花鲈早
江边的随想（节选） 一 春天是一个从句 它招來蜂，引来蝶 带来一条从冬天流来的江 一条江是另一个从句 它捎来鱼虾，引来水草…… 吸引无数的人前来凭吊 江底的那个人，从水中站起 他身无长物，只有满目山河 二 看过许多条江 还是这条江最重，它拖着 一个沉重的灵魂 涌向历史的纸页 每个读过的人 从内到外，浑身都湿漉漉的 每个在里面泅渡的人 都很难上岸
在相同遗传背景下，黄籽油菜具有高含油量和高蛋白质含量、低粗纤维含量、低酚类化合物含量，不及黑籽产生的大量具有苦涩味的单宁、鞣酸等多酚化合物，油的品质好，蛋白质可消化率较高和检察种子成熟较易等优点，鉴于黄籽油菜的诸多优良特性，选育黄籽类型品种则被国内外油菜育种工作者作为改造甘蓝型油菜品质的一条非常重要途径。但甘蓝型黄籽油菜种皮色泽与白菜型和芥菜型油菜种皮色泽的遗传行为明显不同。在研究甘蓝型黄籽油菜的
Aim: To define the effect of resveratrol (RES) on the central regulation of blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA). M
Aim: To investigate whether the prophylactic local delivery of mobilized periph-eral blood mononuclear cells (M-PBMNC) could prevent peripheral microangio-pathy
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
Flavonoids are found ubiquitously in higher plants and constitute an important component of the majority of peoples’ daily diets. The biological activities of
超蜂窝架构通过控制覆盖与业务覆盖的适度分离,使得业务基站休眠成为可能,实现按需调节业务覆盖,提升网络能效.但业务基站休眠会对业务延时带来潜在影响.为此,定量分析基站休