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目的 研究 PCOS患者血清、卵泡液中 IGF- 水平的改变。方法 对 11例 PCOS患者和 11例月经周期正常妇女进行早卵泡期末梢血和卵泡液 IGF- 水平测定 ,比较 IGF- 在 PCOS组与对照组研究对象之血清与卵泡液中水平的差异。结果 两组血清 IGF- 差异无统计学意义 ;PCOS组卵泡液中 IGF- 明显高于对照组 ;同组血清与卵泡液中的 IGF- 差别无统计学意义。结论 IGF- 可能主要是通过血液渗透至卵泡液发挥作用 ,PCOS患者卵泡液 IGF- I改变可能和 PCOS的发生有关。
Objective To study the changes of IGF-levels in serum and follicular fluid of patients with PCOS. Methods 11 cases of PCOS patients and 11 cases of normal menstrual cycle women with early stage of follicular fluid and follicular fluid IGF-levels were measured IGF- in PCOS group and control subjects in the serum and follicular fluid levels were compared. Results There was no significant difference in serum IGF-1 levels between the two groups. IGF-1 in follicular fluid of PCOS group was significantly higher than that of control group. There was no significant difference in serum IGF-1 between the two groups. CONCLUSION IGF-1 may play a role mainly through blood penetration into follicular fluid. The change of follicular fluid IGF-I in PCOS may be related to the occurrence of PCOS.