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目的观察阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-hypopnea Syndrome,OSAHS)患者及OSAHS相关高血压(OSAHAHT)患者血清中氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)及铜锌超氧化物歧化酶(copper-zinc superoxide dismutase,CuZnSOD)水平的变化。方法选择OSAHS及OSAHAHT患者各20例及健康对照组20例,应用酶联免疫吸附试验检测血清中ox-LDL水平,用黄嘌呤氧化酶法检测血清中CuZnSOD水平,并与睡眠监测指标进行相关分析。结果与对照组比较,OSAHS及OSAHAHT组患者血清中ox-LDL浓度升高,CuZnSOD浓度降低(P<0.01),差异有统计学意义(P<0.01)。OSAHS及OSAHAHT组患者血清中ox-LDL、CuZnSOD水平与反映睡眠呼吸暂停严重程度的指标有相关性(P<0.01)。结论 OSAHS及OSAHAHT患者血清中ox-LDL及CuZnSOD水平有变化,存在氧化应激,血清中ox-LDL及CuZnSOD水平可以反映OSAHS患者的病情严重程度。
Objective To observe the changes of serum oxidized low density lipoprotein (ox-LDL) and copper in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and OSAHS-related hypertension (OSAHAHT) Changes of copper-zinc superoxide dismutase (CuZnSOD) levels. Methods 20 patients with OSAHS and OSAHAHT and 20 healthy controls were enrolled in this study. Serum levels of ox-LDL were detected by enzyme-linked immunosorbent assay (ELISA). CuZnSOD level in serum was detected by xanthine oxidase method and correlated with sleep monitoring parameters . Results Compared with the control group, the concentration of ox-LDL and the concentration of CuZnSOD in OSAHS and OSAHAHT groups were significantly decreased (P <0.01). The difference was statistically significant (P <0.01). The serum levels of ox-LDL and CuZnSOD in OSAHS and OSAHAHT patients correlated with the severity of sleep apnea (P <0.01). Conclusions The levels of ox-LDL and CuZnSOD in serum of patients with OSAHS and OSAHAHT are changed and oxidative stress exists. The levels of ox-LDL and CuZnSOD in serum can reflect the severity of illness in patients with OSAHS.