1978年Martin与Romer在研究抗组胺药物时,发现一种三环化合物—苯环庚噻吩(Benzocycloheptafhiophen,噻哌酮)又名(Ketotifen,酮替芬),该药在当年即作为H_1受体拮抗剂在瑞士产售,目前国内亦已生产使用。酮替芬是目前抗组胺药物中作用最强的新药,由于它在预防性治疗支气管哮喘和对某些过敏性疾病的治疗方面有较好的效果,而且使用方便、副作用少,因此认为是一种颇有前途的平喘 When Martin and Romer studied antihistamines in 1978, they discovered that a tricyclic compound, Benzocycloheptafhiophen (Ketotifen), also known as ketotifen, was used in the same year as the H 1 receptor Antagonists are on the market in Switzerland and are currently in production in the country. Ketotifen is currently the most potent new drug among antihistamines. Because of its good effect in the prophylactic treatment of bronchial asthma and the treatment of certain allergic diseases, ketotifen is considered to be easy to use and has few side effects A promising asthma