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目的探讨有氧运动及其联合人参茎叶皂苷对高脂血症小鼠脂质代谢的影响。方法用高脂膳食喂养小鼠建立高脂血症模型，用无负重游泳方式作为有氧运动，观察有氧运动联合人参茎叶皂苷对小鼠血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、丙二醛（ＭＤＡ）、胸腺和肝重以及肝形态的影响。结果与高脂模型组比较，①单纯有氧运动使高脂状态下小鼠的血清ＴＣ、ＴＧ降低（Ｐ＜０．０５），ＭＤＡ降低不显著（Ｐ＞０．０５），胸腺和肝重变化不大（Ｐ＞０．０５），肝脂肪样变不消失。②人参茎叶皂苷显著降低ＴＣ、ＭＤＡ（Ｐ＜０．０５），ＴＧ降低不明显，胸腺增重（Ｐ＜０．０５）而肝重量减轻（Ｐ＜０．０１），脂肪肝未消失。③有氧运动与人参茎叶皂苷（６０ｍｇ·ｋｇ－１）联合则显著降低ＴＣ、ＭＤＡ和ＴＧ（Ｐ＜０．０１），胸腺增重而肝重减轻且脂肪样变消失。结论有氧运动联合人参茎叶皂苷的降脂、调脂和抗氧化作用比单纯有氧运动或单用人参茎叶皂苷强。
Objective To investigate the effects of aerobic exercise and ginsenosides on lipid metabolism in mice with hyperlipidemia. Methods Hyperlipidemia mice were fed with a high-fat diet, and aerobic exercise was used to observe the changes of serum total cholesterol (TC), triglyceride (TG) , Malondialdehyde (MDA), thymus and liver weight and liver morphology. Results Compared with hyperlipidemic model group, the levels of serum TC and TG were decreased (P <0.05) and the MDA was not significantly decreased (P> 0.05). The thymus and liver weight Little change (P> 0.05), hepatic steatosis does not disappear. ② Ginseng stem and leaf saponin significantly reduced TC, MDA (P <0.05), TG decreased insignificantly, thymus weight gain (P <0.05) and liver weight loss (P <0.01), fatty liver did not disappear. ③ Aerobic exercise combined with ginseng stem and leaf saponin (60mg · kg-1) significantly reduced TC, MDA and TG (P <0.01). Thymus weight gain and liver weight loss and fat-like change disappeared. CONCLUSION Aerobic exercise combined with ginsenosides is more effective in lowering lipid, regulating lipid and anti-oxidation than simple aerobic exercise or single use of ginseng stem and leaf saponin.