溴中毒于1930-1940年问发病率很高,之后新的巴比土酸盐类问世,临床使用溴剂减少,发病率随即下降,近年很少文献报导。但是,对心脏病患者使用不当,仍易造成中毒。本院因缺乏氯化钾,曾对5例风湿性心脏病患者投给溴化钾补充钾盐,服用后均发生了澳中毒,临床表现相似,血溴定量均超过100毫克％可确定为溴中毒,就此作了文献复习,并附一例报告,对中毒机制、临床表现等作了简要叙述,以期提高警惕,避免再度发生。除心脏病患者外,溴中毒亦常见于老年体弱、动脉硬化、慢性肾脏疾病、贫血及高度情绪波动患者。对以上情况,使用溴剂时亦需注意。溴中毒发病机制与溴的体内代谢特点有直接关系。1894年Nencki等首先发现溴的代谢与氯十分近似,而且溴能代替部分组织内(包括体液)的氯离子从而引起中毒。在肠道内溴与氯同时存在时,溴比氯更易吸收。如每日摄入3-5克溴,应每日摄入氯15克方不至发生溴中毒,但一般均不能摄足此量。等量摄入氯与溴离子普通治疗量3周内即可发生中毒 Bromine poisoning in 1930-1940 ask the incidence rate is very high, after the advent of new barbiturates, the clinical use of bromine decreased, the incidence decreased, in recent years little literature. However, improper use of heart disease can still cause poisoning. Due to the lack of potassium chloride in our hospital, 5 cases of patients with rheumatic heart disease were given potassium bromide potassium supplements. Oral toxicity occurred after taking the drugs. The clinical manifestations were similar. Blood bromine levels exceeded 100 mg% Poisoning, made a review of the literature, with a case report on the poisoning mechanism, clinical presentation made a brief description, with a view to raising vigilance to avoid recurrence. In addition to heart disease, bromine poisoning is also common in the elderly frail, atherosclerosis, chronic kidney disease, anemia and high mood swings. The above situation, the use of bromine also need attention. The pathogenesis of bromine poisoning is directly related to the in vivo metabolism of bromine. In 1894, Nencki et al. First found that bromine metabolism is very similar to chlorine, and bromine can replace chlorine ions in some tissues (including body fluids) to cause poisoning. Bromine is more readily absorbed than chlorine when both bromine and chlorine are present in the intestine. Such as daily intake of 3-5 grams of bromine should be daily intake of 15 grams of chlorine will not occur bromine poisoning, but generally can not take enough of this amount. The same amount of chlorine and bromide intake of normal treatment can occur within 3 weeks of poisoning