目的　探讨隐球菌性脑膜炎的诊治方法。方法　对 17例隐球菌性脑膜炎患者的临床资料进行回顾性分析。结果　治愈 5例 ,好转 6例 ,死亡 2例 ,病情无变化 3例 ,自动出院 1例。结论　反复多次脑脊液涂片检查是确诊的关键 ,隐球菌抗原乳胶凝结试验和隐球菌聚合酶链反应技术可使阳性率达 90 %以上。治疗原则 :多种抗霉菌药物联合治疗 ,多途径给药。 Objective To investigate the diagnosis and treatment of cryptococcal meningitis. Methods The clinical data of 17 patients with cryptococcal meningitis were retrospectively analyzed. Results of 5 cases cured, improved in 6 cases, 2 died, no change in 3 cases, 1 case of spontaneous discharge. Conclusion Repeated multiple cerebrospinal fluid smear examination is the key to diagnosis. Cryptococcal antigen latex coagulation test and Cryptococcus neoformans polymerase chain reaction can make the positive rate more than 90%. Treatment principles: a variety of anti-fungal drug combination therapy, multi-route administration.