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目的调查佛山市三甲医院ICU铜绿假单菌医院获得性感染的分子流行病学情况。方法随机选取佛山市三甲医院2009年2月-2013年4月接受的ICU患者83人,用无菌容器采取标本,包括采取患者的血液、尿液和痰以及患者居住病房的标本如水、空气和物体表面采样等,将标本送检。同时将临床常用的抗生素给予上述患者,观察药物对患者的作用。结果在送检的标本中,痰的检出率为(72.29%),血液检出率为(8.43%),尿液检出率为(6.02%),伤口分泌物检出率为(10.84%),环境检出率为(5.53%)。抗生素的作用以半合成的青霉素作用最明显。结论使用分子流行病学调查此项目科学有效,铜绿假单菌是人类正常菌群,它喜好潮湿的环境,由于吸引器的橡皮管是经过消毒后备用的,所以最容易滋生病菌,而病房由于医务人员的活动等各种因素导致铜绿假单菌滋生,造成其对患者的感染。半合成青霉素的使用能够降低铜绿假单菌的感染。
Objective To investigate the molecular epidemiology of acquired infection of ICU Pseudomonas aeruginosa in the top three hospital of Foshan City. Methods A total of 83 ICU patients were randomly selected from the top three hospitals of Foshan City from February 2009 to April 2013. The specimens were collected in sterile containers, which included taking samples of blood, urine and sputum of patients and living ward of patients, such as water and air Sampling the surface of the object, the specimen submission. At the same time, clinical antibiotics are given to the above patients to observe the effect of the drugs on the patients. Results The detection rate of sputum was 72.29%, the detection rate of blood was 8.43%, the detection rate of urine was 6.02% and the detection rate of wound secretion was 10.84% ), The environmental detection rate was (5.53%). The role of antibiotics to semi-synthetic penicillin most obvious. Conclusion The molecular epidemiological investigation of this project is scientific and effective. Pseudomonas aeruginosa is a normal flora of human beings. It prefers wet environment. As the rubber tube of the aspirator is sterilized and reserved, it is most likely to breed germs, Various factors such as the activities of medical staff led to the growth of Pseudomonas aeruginosa, causing its infection to patients. The use of semi-synthetic penicillin can reduce Pseudomonas aeruginosa infection.