多肽:N-乙酰氨基半乳糖转移酶2是O-糖链合成第一步的糖基转移酶,而O-糖基化与血管内皮细胞的功能密切相关。随着近年来人类基因组计划的迅速发展,人们对糖基转移酶的功能也开始有了新的认识。本文采用RT—PCR法观察了六种不同组织中PP-CallNAC-T2的表达水平,发现PP—GalNAc—T2在胃肠道粘膜等呈高表达,在脑组织中也有一定的表达,提示它在不同组织中的分布与组织功能存在相关性,值得进一步研究。 Polypeptide: N-acetylgalactosaminyltransferase 2 is the first step of sugar chain synthesis glycosyltransferase, and O-glycosylation is closely related to the function of vascular endothelial cells. With the rapid development of the human genome project in recent years, people have begun to gain new understanding of the function of glycosyltransferases. In this paper, the expression of PP-CallNAC-T2 in six different tissues was observed by RT-PCR and found that PP-GalNAc-T2 was highly expressed in the gastrointestinal mucosa and so on, and also expressed in brain tissue, suggesting that PP- There is a correlation between the distribution in different tissues and the function of the tissue, which deserves further study.