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目的:探讨白塞综合征的临床特点、实验室检查以及药物治疗,提高对该病的认识,更好的为临床诊疗工作提供参考,从而更加有效的进行对此病的治疗。方法:收集了新疆医科大学第一附属医院2009年1月~2013年6月期间就诊于口腔颌面外科、风湿免疫科及皮肤科病房诊治的白塞综合征患者。对发病年龄、性别、临床表现、实验室检查、治疗方案及疗效等项目列表登记,应用统计学方法得出相关结论。结果:本组资料患者共114例,男性52例(45.61%),女性62例(54.39%),各年龄段均可发病,发病年龄不存在性别差异(P>0.05)。症状按发生频率由高到低排列为:口腔溃疡114例(100%),皮肤损害76例(66.67%),生殖器溃疡20例(17.54%),发热25例(21.93%),统计分析后均不存在性别差异(P>0.05)。汉族与维吾尔族的发病类型存在差异(P<0.05);针刺反应阳性51例(44.74%),统计分析后存在性别差异(P<0.05)。常规实验室检查异常指标中:白细胞计数增加、红细胞沉降率增快存在明显性别差异。沙利度胺联合泼尼松治与免疫抑制剂联合泼尼松治疗白塞综合征效果明显优越与单一使用泼尼松。结论:白塞综合征各年龄均可发病,临床表现多样,针刺反应阳性存在显著性别性差异,民族之间不同类型存在差异,联合用药治疗效果明显优于单一用药。
Objective: To investigate the clinical characteristics of Behcet’s syndrome, laboratory tests and drug therapy to improve the understanding of the disease, and better provide a reference for clinical diagnosis and treatment, so as to more effectively treat the disease. Methods: The patients with Behcet’s syndrome who were admitted to the Department of Oral and Maxillofacial Surgery, Rheumatology and Dermatology ward from January 2009 to June 2013 in the First Affiliated Hospital of Xinjiang Medical University were collected. The age of onset, gender, clinical manifestations, laboratory tests, treatment programs and the efficacy of the list of items registered, the application of statistical methods to draw the relevant conclusions. Results: A total of 114 patients were included in this study. There were 52 males (45.61%) and 62 females (54.39%). There were no significant differences in age at onset (P> 0.05). Symptoms were arranged according to the frequency from high to low: oral ulcer in 114 cases (100%), skin damage in 76 cases (66.67%), genital ulcer in 20 cases (17.54%) and fever in 25 cases (21.93% There was no gender difference (P> 0.05). The incidence of Han and Uygur patients was different (P <0.05). Acupuncture reaction was positive in 51 cases (44.74%). There was gender difference after statistical analysis (P <0.05). Routine laboratory abnormalities indicators: increased white blood cell count, erythrocyte sedimentation rate increased significantly gender differences. Thalidomide combined with prednisone and immunosuppressive agents prednisone in the treatment of Behçet’s syndrome was significantly superior to prednisone alone. CONCLUSION: Behcet’s syndrome can develop in all ages and has various clinical manifestations. There are significant gender differences in acupuncture-positive reactions. There are differences among different ethnic groups. The combination therapy is superior to single-agent treatment.