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Objective: To investigate the causes of bladder explosion during transurethral plasmakinetic resection of prostate and to explore effective measures to reduce the risk of bladder explosion. Methods: The treatment process of bladder rupture (2cases) and bladder muscle layer laceration (1case) during transurethral plasmakinetic resection of prostate were retrospectively analyzed.Results: Two cases with intra-peritoneal rupture were cured by open surgery, and 1case with bladder muscle layer laceration was cured by conservative treatment.The main cause of bladder explosion is that: the flammable gas produced during the resection of prostate tissue mixed with the gas from the outside into the bladder to a certain proportion, in the action of electric spark, causing gas explosion.Conclusions: Using dorsal elevated position, shortening operative time, and reducing gas entering the bladder are three key points to prevent bladder explosion.