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目的探讨糖耐量减低(IGT)患者高甘油三酯血症-腰围表型(HTWC)与早期认知障碍(MCI)的相关性。方法将200例IGT患者分为4组,即甘油三酯与腰围正常组(A组)45例、单纯腹型肥胖组(B组)49例、单纯高甘油三酯组(C组)48例、高甘油三酯血症-腰围表型(HTWC)组(D组)58例。测定所有对象的空腹血糖(FPG)、OGTT、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、身高、体质量、腰围、臀围、血压、IMT等。对各组患者应用MMSE表和MOCA表进行认知评估。结果 D组MMSE与MOCA评分明显低于其他3组(P<0.01);D组的MCI患病率明显高于其他3组(P<0.01)。结论高甘油三酯血症-腰围表型与早期认知障碍存在相关性。
Objective To investigate the relationship between hypertriglyceridemia-waistline phenotype (HTWC) and early cognitive impairment (MCI) in patients with impaired glucose tolerance (IGT). Methods 200 patients with IGT were divided into 4 groups: 45 cases of triglyceride and normal waist circumference (group A), 49 cases of abdominal obesity group (group B), 48 cases of simple hypertriglyceridemia group (group C) , Hypertriglyceridemia - waist circumference phenotype (HTWC) group (D group) 58 cases. Fasting blood glucose (FPG), OGTT, HbA1c, TC, TG, HDL-C, LDL-C were measured in all subjects C), height, weight, waist circumference, hip circumference, blood pressure, IMT and so on. Each group of patients using MMSE table and MOCA table for cognitive assessment. Results The scores of MMSE and MOCA in group D were significantly lower than those in other three groups (P <0.01). The prevalence of MCI in group D was significantly higher than that in the other three groups (P <0.01). Conclusions There is a correlation between hypertriglyceridemia-waistline phenotype and early cognitive impairment.