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目的调查男性艾滋病病毒(HIV)阳性者的支原体感染情况,探索支原体感染与HIV阳性者免疫功能状况之间的关系。方法问卷调查人口学特征、临床表现、高危行为史等基本信息;采集首段尿检测解脲脲原体(Uu)、人型支原体(Mh)、生殖支原体(Mg)、发酵支原体(Mf)、穿通支原体(Mpe)和梨支原体(Mpi);采集外周静脉血检测CD4+、CD8+T淋巴细胞计数水平及白介素-2(IL-2)、白介素-4(IL-4)、白介素-6(IL-6)、白介素-10(IL-10)、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)表达水平。结果江苏省男性HIV感染者中Uu、Mh、Mg、Mf、Mpe、Mpi的感染率分别为51.7%(257/497)、34.0%(169/497)、29.0%(144/497)、6.6%(33/497)、1.6%(8/497)、16.3%(81/497);男性HIV感染者中CD4+T细胞<200个/μL有108例,占21.8%,200～499个/μL有252例,占50.9%;外周血中IL-2、IL-4、IL-6、IL-10、IFN-γ、TNF-α含量中位数分别为145.059、1.315、0.420、2.405、4.083、7.157 ng/mL;感染了艾滋病相关支原体的男性HIV感染者外周血的CD3+、CD4+、CD8+细胞计数水平以及TNF-α的表达水平均明显低于未感染艾滋病相关支原体的男性HIV感染者。结论 6种致病性支原体在江苏省男性HIV感染者体内均有不同程度感染,可能与机体免疫功能状况存在关联,应引起临床足够重视。
Objective To investigate the prevalence of Mycoplasma infection in HIV-positive men and explore the relationship between Mycoplasma infection and immune status in HIV-positive people. Methods The questionnaires were used to investigate demographic characteristics, clinical manifestations and high-risk behavioral history. The first urine samples were collected for urinary UU, Mh, M, Mf, (Mpe) and Mycoplasma penetrans (Mpi) were collected. Peripheral venous blood samples were collected to detect CD4 +, CD8 + T lymphocyte count and interleukin-2, interleukin-4, -6, IL-10, IFN-γ and TNF-α were measured. Results The prevalences of Uu, Mh, Mg, Mf, Mpe and Mpi in HIV-infected men were 51.7% (257/497), 34.0% (169/497), 29.0% (144/497) (33/497), 1.6% (8/497) and 16.3% (81/497) respectively. There were 108 cases with CD4 + T cells less than 200 / μL in HIV-infected men, accounting for 21.8% and 200-499 / μL The median of IL-2, IL-4, IL-6, IL-10, IFN-γ and TNF-αin the peripheral blood was 145.059,1.315,0.420,2.405,4.083 respectively, 7.157 ng / mL. The counts of CD3 +, CD4 +, CD8 + and TNF-α in peripheral blood of HIV-infected patients with HIV-related mycoplasma were significantly lower than those without HIV-related mycoplasma. Conclusions Six kinds of pathogenic Mycoplasma are infected to varying degrees in HIV-infected men in Jiangsu Province, which may be related to the immune status of the body, which should be paid enough attention in clinic.