成人特发性膜性肾病是肾病综合征的常见原因,约有50%病人在症状出现后10～15年内出现晚期肾功能衰竭或死亡。关于本病如何治疗尚有争论。作者研究应用甲基强的松龙及苯丁酸氮芥的新疗法对特发性膜性肾病的效果,67例肾病综合征患者,尿蛋白排出>3.5克/天、血浆白蛋白<2.5克/100毫升、水肿、肾组织活 Adult idiopathic membranous nephropathy is a common cause of nephrotic syndrome, with about 50% of patients presenting with advanced renal failure or death 10 to 15 years after the onset of symptoms. How to treat the disease is still controversial. The authors investigated the effect of a new regimen of methylprednisolone and chlorambucil on idiopathic membranous nephropathy in 67 patients with nephrotic syndrome with urinary protein excretion> 3.5 g / day and plasma albumin <2.5 g / 100 ml, edema, renal tissue activity