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本文报道了7例严重型毛细胞白血病的强烈化疗。病人的中位数年龄为47岁(36—58),7例中6例有脾肿大。在治疗前均曾行脾切除术,有轻微和短暂的血液学反应。其中2例达到Catovsky的完全缓解标准,但分别在20和56月后复发。1例无脾肿大和脾扣留,未行外科治疗。6例有贫血,5例需要每月输红细胞,5例有血小板减少,7例均有持续性粒细胞减少并发反复感染。4例曾用甲基强地松龙治疗,有轻微、短暂的血象改变。1例曾用碳酸锂治疗无任何效果。化疗方案:苯甲酰腙柔红霉素450mg/m~2,静滴,第一天,阿糖胞苷200mg/m~2/d,持续静滴,第1—5天;环磷酰胺2000mg/m~2,静注,第5天。结果:4例有效,其中3例完全缓解,1例部分缓解。疗效持续时间分别为44、24、15和23个月。4
This article reports the intensive chemotherapy of seven cases of severe hairy cell leukemia. The median age of patients was 47 years (36-58), and 6 of 7 had splenomegaly. Splenectomy was performed before treatment with mild and transient hematologic reactions. Two of them achieved Catovsky’s complete remission, but relapsed after 20 and 56 months, respectively. One case without splenomegaly and spleen detained, no surgical treatment. 6 patients had anemia, 5 patients required monthly transfusion of red blood cells, 5 patients had thrombocytopenia, 7 patients had persistent neutropenia and recurrent infections. 4 cases had used methylprednisolone treatment, a slight, transient changes in blood. One case had been treated with lithium carbonate without any effect. Chemotherapy regimen: benzoylhydrazone daunorubicin 450mg / m ~ 2, intravenous infusion, the first day, cytarabine 200mg / m ~ 2 / d, continuous intravenous infusion, 1-5 days; cyclophosphamide 2000mg / m ~ 2, intravenous injection, the first 5 days. Results: 4 cases were effective, 3 cases were completely relieved, 1 case partially relieved. Duration of efficacy were 44, 44, 15 and 23 months respectively. 4