当细胞遇到温度骤然升高时会产生热休克蛋白(HSP)。Ritossa 于1962年最早指出在热休克后,果蝇的唾液腺染色体出现一种新的膨松模式。此后这种应答的普遍性逐渐被证实。起初认为HSP 只在高温下才能阻止蛋白质的去折叠,后来发现除热以外的许多刺激也能诱导HSP 的生成,于是应急蛋白”一词应运而生.现已知道HSP 具有重要 Heat shock proteins (HSPs) are produced when cells experience sudden increases in temperature. Ritossa first pointed out in 1962 that after heat shock, the Drosophila salivary gland chromosome appeared a new bulking pattern. The universality of this response has since been gradually confirmed. It was initially thought that HSP only prevents the unfolding of the protein at high temperatures and later found that many stimuli other than heat also induce the production of HSP, and that the term emergent arises. It is now known that HSP is important