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目的：探讨层粘蛋白（ＬＮ）及血管内皮完整性受损在妊高征及妊娠期肝内胆汁淤积症（ＩＣＰ）等并发症发病中的作用和意义。方法：测定４０４例妊娠晚期孕妇血清ＬＮ浓度，比较对照组、妊高征组、ＩＣＰ组、羊水过少组、ＩＵＧＲ组和巨大儿组血清ＬＮ水平的差异。结果：妊高征组和ＩＣＰ组血清ＬＮ水平显著高于对照组，差异有显著性（均Ｐ＜００１）；羊水过少、ＩＵＧＲ及巨大儿组与对照组差异无显著性（均Ｐ＞００５）；轻度、中度和重度妊高征间差异无显著性（均Ｐ＞００５）。结论：血清ＬＮ升高可能与妊高征及ＩＣＰ等并发症的发病过程有关。
Objective: To investigate the role and significance of laminin (LN) and vascular endothelial integrity impairment in the pathogenesis of complications such as pregnancy induced hypertension (PIH) and intrahepatic cholestasis of pregnancy (ICP). Methods: Serum LN concentration was measured in 404 pregnant women of the third trimester. The serum levels of LN in control group, PIH group, ICP group, oligohydramnios group, IUGR group and Giant children group were compared. Results: The levels of serum LN in PIH group and ICP group were significantly higher than those in control group (all P <001), oligohydramnios, IUGR and macrosomia group were not significantly different from those in control group (P > 005). There was no significant difference between mild, moderate and severe PIH (all P> 005). Conclusion: Elevated serum LN may be related to the pathogenesis of complications such as PIH and ICP.