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目的检测DM早期及糖尿病足(DF)0级血浆羧甲基赖氨酸(CML)水平,并探讨CML与糖代谢、病程、年龄的相关性。方法 45例DM早期患者(参照1999年WHO糖尿病诊断标准,且尿白蛋白排泄量<200μg/min或300mg/d;视网膜病变≤Ⅰ期),35例DF为0级的患者(参照Wagner诊断分级标准),检测空腹状态下血浆CML、FPG、HbA1c及PPG。结果 DF组较DM早期组年龄较大、病程较长,血浆CML水平明显升高(P<0.05)。DF 0级患者血浆CML水平在血糖控制不佳患者(HbA1c>7.0%)中显著升高,且均与HbA1c呈显著正相关(r=0.44,P<0.01);同时,CML与2hPG也呈显著正相关(r=0.41,P<0.05),CML与FPG、病程、年龄均无相关性(P>0.05)。结论 DF 0级患者CML水平显著升高,血浆CML与HbA1c、2hPG呈正相关,血浆CML也许是糖氧化的生物标记,且与糖尿病相关并发症有关。
Objective To detect plasma level of carboxymethyl lysine (CML) of DM 0 and diabetic foot (DF) 0 and investigate the relationship between CML and glucose metabolism, duration and age. Methods Forty-five patients with early stage DM (according to WHO diagnostic criteria for diabetes and 1999 urinary albumin excretion <200μg / min or 300mg / d and retinopathy ≤Ⅰ) and 35 patients with DF as grade 0 (according to Wagner diagnostic classification Standard), detection of fasting plasma CML, FPG, HbA1c and PPG. Results Compared with the early stage of DM group, the DF group had a longer age, a longer course and a significantly higher plasma CML level (P <0.05). The level of plasma CML in patients with DF 0 level was significantly higher in patients with poor blood glucose control (HbA1c> 7.0%), and both were positively correlated with HbA1c (r = 0.44, P <0.01). Meanwhile, CML and 2hPG were also significantly (R = 0.41, P <0.05). There was no correlation between CML and FPG, duration of disease and age (P> 0.05). Conclusions The level of CML in patients with DF 0 grade is significantly higher than that in patients with normal grade C, plasma CML is positively correlated with HbA1c and 2hPG, and plasma CML may be a biomarker of carbohydrate oxidation and is associated with complications related to diabetes.