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通过对34名平原人乘飞机进驻海拔4370m 高原后尿蛋白的动态分析和急性高原病(AMS)的调查,我们看到,受试者在达高原的1～3天内尿蛋白阳性率为20.6～26.5%,尿潜血反应阳性率为5.9～14.8%,4天后均接近平原值;AMS 者的尿蛋白浓度明显高于未患AMS 者(28.9±4.4v.s.17.1±2.2,p<0.05);在AMS 患者中,69.2%的人(9/13)尿蛋白阳性,30.8%的人(4/13)尿蛋白可疑,而且尿蛋白阳性者的AMS 症状持续的时间明显长于非尿蛋白阳性者(4.4±0.1v.s.3.6±0.1,p<0.05)。上述结果提示,平原人在快速进驻高原初期肾功能会受到严重影响,但经短期高原适应后是可以很快恢复的;AMS 与高原性蛋白尿有密切的关系;蛋白尿的产生可能是由肾小球基底膜受损后通透增加所致。
Through the dynamic analysis of urinary protein in 34 plains at 4370m above sea level and the investigation of acute high altitude sickness (AMS), we found that the positive rate of urinary protein in subjects within 1 ~ 3 days of reaching the plateau was 20.6 ~ 26.5%, urinary occult blood reaction positive rate was 5.9 ~ 14.8%, 4 days after the close to the plain value; AMS urinary protein concentrations were significantly higher than those without AMS (28.9 ± 4.4vs17.1 ± 2.2, p <0.05) Of the patients, urinary protein was positive in 69.2% (9/13), urine protein in 30.8% (4/13) was suspicious, and duration of AMS symptoms in urine protein positive patients was significantly longer than that in non-urine protein positive patients (4.4 ± 0.1 vs 3.6 ± 0.1, p <0.05). The above results suggest that plain people may be seriously affected in the early stage of rapid plateau access to renal function, but after a short-term altitude adaptation can be quickly restored; AMS and altitude proteinuria are closely related; proteinuria may be caused by the kidney Broken ball basement membrane damage caused by increased permeability.