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目的探讨血清胱抑素C(Cys C)对于冠心病患者心血管事件的预测价值是否独立于肾功能。方法共有305例患者入组,主要统计Cys C、超敏C反应蛋白((hs-CRP)、肾小球滤过率(e GFR)和冠脉积分,以血清Cys C水平为标准,按四分位数分四组,然后做相关性分析。结果 1冠心病组Cys C水平(0.83±0.35)显著高于对照组(0.72±0.24),两组比较,差异具有统计学意义(P<0.01)。2冠状动脉病变严重程度评分随血清Cys C水平的升高而逐渐加重。3 Cys C与炎症指标hs-CRP、纤维蛋白原相关。4 Cys C是独立于e GFR的冠心病的预测指标。结论本研究认为Cys C作为一种理想的反映GFR变化内源性标志物,与冠心病有明显相关性,是独立于e GFR,并且提示炎症是联系Cys C与CAD的重要因素。
Objective To investigate whether the predictive value of serum cystatin C (Cys C) for cardiovascular events in patients with coronary heart disease is independent of renal function. Methods A total of 305 patients were enrolled in the study. The main statistics were Cys C, hs-CRP, e GFR and coronary artery score. The serum Cys C level was used as the standard, The quantile was divided into four groups and then the correlation was analyzed.Results 1 The level of Cys C in coronary heart disease group (0.83 ± 0.35) was significantly higher than that in control group (0.72 ± 0.24), the difference was statistically significant (P <0.01 ) .2 The severity of coronary artery disease severity scores progressively increased as serum levels of Cys C increased.3 Cys C correlated with hs-CRP, fibrinogen.4 Cys C was a predictor of coronary disease independently of e GFR .Conclusions This study suggests that Cys C, as an ideal endogenous marker reflecting GFR changes, has a significant correlation with coronary heart disease and is independent of e GFR and suggests that inflammation is an important factor in the relationship between Cys C and CAD.