主动免疫治疗在延长白血病患者化疗后无病生存期以及消除微小残留病变中发挥着重要作用,其基本原理是用肿瘤抗原激发机体免疫系统消灭残存的肿瘤。白血病细胞疫苗以及负载白血病抗原的树突状细胞疫苗可诱导机体产生特异性免疫应答,在小鼠体内已显示了抗肿瘤效应,并已有部分进入了Ⅰ/Ⅱ期临床试验阶段,具有较好的应用前景,值得进一步研究。 Active immunotherapy plays an important role in prolonging disease-free survival after chemotherapy and eliminating minimal residual disease in patients with leukemia. The basic principle is to use tumor antigens to stimulate the body’s immune system to eliminate residual tumors. Leukemia cell vaccine and dendritic cell vaccine loaded with leukemia antigen can induce the body to produce a specific immune response in mice has shown anti-tumor effect, and some have entered Phase Ⅰ / Ⅱ clinical trial phase, with better The application prospects, it is worth further study.