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以脱镁叶绿酸a甲酯为起始原料 ,通过与溴化氢的加成和四氧化锇的氧化反应对 2 位乙烯基进行化学修饰 ,合成了 2 位羟烷基或溴烷基取代的脱镁叶绿酸衍生物 ,再利用邻二醇的碳碳键断裂和羟乙基的氧化生成 2 位甲酰基脱镁叶绿酸a甲酯和 2位乙酰基焦脱镁叶绿酸a甲酯。
Taking pheophorbide a methyl ester as the starting material, the 2-position vinyl group was chemically modified by the addition of hydrogen bromide and osmium tetroxide to synthesize the 2-hydroxyalkyl or bromoalkyl substituted Of pheophorbide derivatives, and then the use of vicinal diol carbon-carbon bond cleavage and hydroxyethyl oxidation of 2-formyl-pheophorbide a methyl ester and 2-acetyl-pyropheophorbide a Methyl ester.