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检查环境中致癌物质的方法有癌原性试验及变异原性试验,但这些方法都受到各种条件的限制。Solt 等通过部分切除大白鼠肝脏的方法,在短时期内发现了癌前病变发生的事实。Ito 等据此进行了种种试验研究,最近还确立了在短期间内检出致癌物质和促催化剂的试验体系。这种方法是以肝谷胱甘肽转移酶(GST-P)阳性细胞巢作为癌前病变的指标,研究了112种化学物质,报告了这种试验体系的可靠性。应用 F344大白鼠,分为三组。第一组经腹腔给予作为启动物的致肝癌物质二乙基亚硝基
Methods of checking for carcinogenic substances in the environment include carcinogenicity tests and mutagenicity tests, but these methods are subject to various conditions. Solt, etc. by partial resection of rat liver method, found in a short period of time the occurrence of precancerous lesions. Ito, etc. conducted a variety of experimental studies accordingly, recently also established a short period of time to detect carcinogens and promote catalyst test system. This method uses liver glutathione transferase (GST-P) positive cell nests as an indicator of precancerous lesions and 112 chemical species are reported, and the reliability of this test system is reported. F344 rats were divided into three groups. The first group was administered intraperitoneally with diethylnitrosotoluene as the hepatic carcinogen